. 2023 Jun 21;11(4):e04548-22. doi: 10.1128/spectrum.04548-22

TABLE 3.

ClpC1 interaction partners for which M. tuberculosis homologs were identified in prior ClpC1 interaction studies

UniProt accession no.	Gene name(s)	Protein description	Identified in prior studies	Mean normalized score	Mean no. of PSMs	Data set(s) observed in
A0QQD0	dnaJ, dnaJ1, MSMEG_0711, MSMEI_0694	Chaperone protein DnaJ1	ClpC1/P2 KD^a	0.676	38.500	WT, EQ, NTD, CORE
A0R203	atpFH, atpF, atpH, MSMEG_4939, MSMEI_4812	ATP synthase subunit b-delta	ClpC1/P2 KD^a	0.568	51.667	WT, EQ, NTD, CORE
I7G417	MSMEI_3879	5-Oxoprolinase	ClpC1/P2 KD^a	0.480	20.500	WT, EQ, NTD, CORE
A0R3L1	MSMEG_5512	Magnesium chelatase	ClpC1/P2 KD,^a BACTH^b	0.410	28.333	WT, EQ, NTD, CORE
A0QQA8	MSMEG_0688, MSMEI_0671	Aspartate aminotransferase	ClpC1/P2 KD^a	0.292	30.500	WT, NTD, CORE
A0R079	glnA, glnA1, MSMEG_4290, MSMEI_4189	Glutamine synthetase (GS)	ClpC1/P2 KD^a	0.162	14.000	WT, NTD
A0R617	pks13, MSMEG_6392, MSMEI_6224	Polyketide synthase	ClpC1/P2 KD^a	0.160	35.333	WT, NTD
A0R200	atpD, MSMEG_4936, MSMEI_4809	ATP synthase subunit beta	ClpC1/P2 KD^a	0.158	11.667	WT, EQ, NTD, CORE
A0R0T1	MSMEG_4497, MSMEI_4386	PhoH family protein	BACTH^b	0.129	9.500	WT, EQ, NTD, CORE
A0QV32	ffh, MSMEG_2430, MSMEI_2369	Signal recognition particle protein (fifty-four homolog)	ClpC1/P2 KD^a	0.126	39.500	WT, NTD, CORE
A0R202	atpA, MSMEG_4938, MSMEI_4811	ATP synthase subunit alpha	ClpC1/P2 KD^a	0.124	14.667	WT, EQ, NTD
A0QQV4	gabD2, MSMEG_0889, MSMEI_0868	Aldehyde dehydrogenase	ClpC1/P2 KD^a	0.123	15.417	WT, EQ, NTD, CORE
A0QQQ1	sodC, MSMEG_0835, MSMEI_0816	Superoxide dismutase	ClpC1/P2 KD^a	0.100	6.500	WT, NTD, CORE
A0R0T8	dnaJ2, MSMEG_4504, MSMEI_4392	Chaperone protein DnaJ2	ClpC1/P2 KD^a	0.094	21.000	WT, CORE
A0QYD6	ndh, MSMEG_3621, MSMEI_3536	NADH dehydrogenase (EC 1.6.99.3)	ClpC1/P2 KD^a	0.093	27.333	WT
A0QR33	hemL, MSMEG_0969, MSMEI_0943	Glutamate-1-semialdehyde 2,1-aminomutase (GSA)	ClpC1/P2 KD^a	0.086	18.500	WT
A0QVU2	MSMEG_2695, MSMEI_2629	35-kDa protein	ClpC1/P2 KD^a	0.083	2.500	EQ, NTD
A0QSY1	MSMEG_1642, MSMEI_1603	ABC transporter, ATP-binding protein	ClpC1/P2 KD,^a BACTH^b	0.083	30.500	WT
A0QX24	moxR, MSMEG_3147	ATPase, MoxR family protein	ClpC1/P2 KD^a	0.073	5.500	WT, EQ, NTD
A0QZ40	tatA, MSMEG_3887, MSMEI_3797	Sec-independent protein translocase protein TatA	ClpC1/P2 KD^a	0.060	4.500	WT, EQ, NTD
A0R1Z9	atpC, MSMEG_4935, MSMEI_4808	ATP synthase epsilon chain	ClpC1/P2 KD^a	0.060	3.000	EQ
A0QT07	sdhB, MSMEG_1669, MSMEI_1629	Succinate dehydrogenase, iron-sulfur protein	ClpC1/P2 KD^a	0.059	6.500	EQ
A0QNN8	pntA, MSMEG_0110, MSMEI_0106	NAD(P) transhydrogenase, alpha subunit (EC 1.6.1.1)	BACTH^b	0.059	18.000	WT
P71533	secA1, MSMEG_1881, MSMEI_1840	Protein translocase subunit SecA 1	ClpC1/P2 KD^a	0.056	28.833	WT, EQ, NTD, CORE
A0QZJ0	MSMEG_4042, MSMEI_3947	Transcriptional regulator, GntR family protein	BACTH^b	0.050	6.000	EQ, CORE
A0R616	MSMEG_6391, MSMEI_6223	Propionyl-CoA carboxylase beta chain	ClpC1/P2 KD^a	0.039	9.500	EQ
Q3L885	pks, MSMEG_0408, MSMEI_0398	Polyketide synthase (type I modular polyketide synthase)	ClpC1/P2 KD^a	0.023	43.000	EQ
A0QQY3	MSMEG_0918, MSMEI_0896	Transcriptional regulator, XRE family protein	BACTH^b	0.019	4.667	WT
A0QSL0	MSMEG_1516, MSMEI_1480	Thioredoxin reductase	ClpC1/P2 KD^a	0.012	9.500	WT, NTD, CORE
A0QR26	MSMEG_0962, MSMEI_0936	TetR family protein transcriptional regulator	ClpC1/P2 KD,^a BACTH^b	0.004	42.000	WT

Lunge et al. (21).

Ziemski et al. (23).