TABLE 2.
Amino acid mutations located in predicted CD8+ T cell epitopes for regions frequently targeted by T cells in SARS-CoV-2 variants
| Protein | No. of predicted epitopes | Parameter | No. (%) in variant |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Delta, B.1.617.2 | Omicron |
|||||||||
| B.1.1.529 | BA.1 | BA.2 | BA.4 | BA.5 | BQ.1 | XBB | ||||
| S | 302 | Amino acid mutations | 2 | 8 | 8 | 9 | 10 | 10 | 12 | 15 |
| Epitopes with amino acid mutation | 8 (3) | 23 (8) | 23 (8) | 20 (7) | 25 (8) | 25 (8) | 35 (12) | 62 (21) | ||
| Epitopes with less/no HLA bindinga | 0 (0) | 13 (4) | 13 (4) | 13 (4) | 13 (4) | 13 (4) | 16 (5) | 18 (6) | ||
| N | 169 | Amino acid mutations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Epitopes with amino acid mutation | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 14 (8) | ||
| Epitopes with less/no HLA bindinga | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 8 (5) | ||
a
Epitopes with percent rank of ≥0.5.