TABLE 2.

Pharmacokinetic parameters and PK/PD ratios of ciprofloxacin in neutropenic rats infected with E. coli ATCC 25922 and P. aeruginosa ATCC 27853 following single i.v. bolus administrations

PK parameter	Mean ± SD for dose (mg/kg):a
	10	30	100
Cmax (μg/mL)	8.95 ± 0.74	22.8 ± 2.0	65.43 ± 4.5
AUC0–∞ (μg·h/mL)	7.78 ± 2.14	23.3 ± 5.1	81.52 ± 2.41
t1/2 (h)	1.54 ± 0.18	3.0 ± 0.29	2.48 ± 0.5
Vss (L/kg)	2.30 ± 0.74	3.95 ± 0.5	3.64 ± 0.33
CL (L/h/kg)	1.35 ± 0.33	1.33 ± 0.3	1.23 ± 0.04
PK/PD ratiosb
fAUC24/MICEc	174	522	1,826
fAUC24/MICPa	44	130	457
fCmax/MICEc	200	511	1,466
fCmax/MICPa	50	128	366

^an = 3.

^bPK/PD ratios were estimated using the unbound concentrations of ciprofloxacin in rat plasma using f_u = 0.7 (see Materials and Methods). MIC_Ec, MIC against E. coli (ATCC 25922); MIC_Pa, MIC against P. aeruginosa (ATCC 27853).