TABLE 3.
Pharmacodynamics of ciprofloxacin in neutropenic rats infected with Escherichia coli ATCC 25922 following single i.v. administrations as bolus and infusionsa
| Treatment | Mean ± SD E. coli burden (log10 CFU/g thigh [reductionb]) |
||
|---|---|---|---|
| i.v. bolus | 30-min i.v. infusion | 1-h i.v. infusion | |
| Infection control (2 h PI) | 6.12 ± 0.41 | NA | NA |
| Vehicle control (26 h PI) | 8.76 ± 0.71 | NA | NA |
| Ciprofloxacin, 26 h PIc (mg/kg) | |||
| 10 | 4.56 ± 0.23d (1.6) | 4.02 ± 0.19d,e (2.1) | 3.72 ± 0.10d,e (2.4) |
| 30 | 4.12 ± 0.27d (2.0) | 3.48 ± 0.33d,f (2.6) | 3.25 ± 0.02d,f (2.9) |
| 100 | 1.77 ± 0.04d (4.4) | BLOQ | BLOQ |
a
BLOQ, below the limit of quantitation; NA, not applicable; PI, postinfection.
b
Values in parentheses indicate the mean reduction in bacterial burden compared to that of the 2-h PI control at 24 h posttreatment.
c
26 h PI is equivalent to 24 h posttreatment.
d
Significantly different compared to 2-h PI control (P < 0.05).
e
Not significantly different compared to 10 mg/kg i.v. bolus (P > 0.05).
f
Not significantly different compared to 30 mg/kg i.v. bolus (P > 0.05).