FIG 7.

In vitro activity of the selected hits against biofilm formation by the P. aeruginosa RP73 strain. Biofilm was allowed to grow for 24 h in the presence of each hit or tobramycin at subinhibitory concentrations (1/2× and 1/4× MIC), and biofilm biomass was measured by crystal violet stain assay. Unexposed control samples were not exposed. Results are shown as individual data points and mean values ± SD (n = 6). Statistical significance: *, P < 0.05, ***, P < 0.001, and ****, P < 0.0001, versus unexposed sample, by one-way ANOVA plus Dunnett’s multiple-comparison posttest; °, P < 0.05, °°, P < 0.01, and °°°°, P < 0.0001, by unpaired t test.