Phage replication and coexistence with K. pneumoniae in the mouse gut. K. pneumoniae BJ1GA-colonized OMM12 mice (n = 28), received PBS (gray, n = 7) or the phages cp1 and mtp5, either together (mix, green; n = 7; 6 × 107 PFU per dose made of the same amount of each phage), or individually (cp1, blue; n = 7; mtp5, orange; n = 7) via oral gavage on days 3, 4, and 5. (A) Levels of K. pneumoniae BJ1-GA in the feces (the arrows represent the days on which the phage[s] was/were given to the mice). (B) The phage titers from the fecal samples that were reported in panel A. (C) The fold-reduction of the bacterial population levels at one day after the first treatment.