FIG 1.

Viability and egg output of adult S. mansoni worms during exposure to nifuroxazide (NFZ) and praziquantel (PZQ). Adult worm pairs were obtained from animals by perfusion at 42 days after infection. Each concentration was tested at least in triplicate, with the highest concentration of DMSO serving as the control. Male (A) and female (B) schistosomes were monitored for up to 72 h, and results are expressed as the percent mortality recorded by Kaplan-Meier survival curves. Eggs released by paired adult worms exposed to NFZ (C). Data are presented as the mean ± SD from three independent experiments (n = 3). Control, drug-free medium; PZQ, praziquantel at 2 μM.