TABLE 3.
Summary of linezolid resistance selection, resistance-associated mutated genes, frequencies of resistance, and resistance phenotypes and levelsa
| Selection condition | Genes with polymorphism | FOR | Resistance phenotypes and levels |
|---|---|---|---|
| LZD high | 23S rRNA | Low | LZD: high |
| Other oxazolidinones: high | |||
| Unrelated drugs: low to high to unaffected | |||
| L3 protein | Low | LZD: high | |
| Other oxazolidinones: high | |||
| Unrelated drugs: unaffected | |||
| LZD low | TetR | High | LZD: low |
| Other oxazolidinones: low to unaffected | |||
| Unrelated drugs: mostly unaffected |