TABLE 1.
C. jejuni isolates_Id | MLST_ST (clonal complex) | Biological sample (isolation source) | Isolation date | Antimicrobial susceptibility (MICs in mg/L) |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Ery | Cip | Tet | Amp | Imp | Ert | Mer | |||||
Case 1 (40-yr-old-male) | A1 | 1709 (ST-1034 clonal complex) | Blood | 26-08-2009 | 0.19 | ≥32 | ≥256 | 24 | 0.032 | 0.047 | 0.023 |
A2 | Blood | 11-11-2009 | ≥256 | ≥32 | ≥256 | 24 | 0.032 | 0.094 | 0.023 | ||
A3 | Stool | 13-11-2009 | ≥256 | ≥32 | 96 | 24 | 0.032 | 0.064 | 0.016 | ||
A4 | Blood | 12-01-2010 | ≥256 | ≥32 | ≥256 | 32 | 0.064 | 64 | 8 | ||
A5 | Blood | 18-01-2010 | ≥256 | ≥32 | ≥256 | ≥256 | 0.19 | 128 | 32 | ||
A6 | Stool | 05-03-2010 | ≥256 | ≥32 | ≥256 | ≥256 | 0.094 | 64 | 8 | ||
A7 | Stool | 15-06-2010 | ≥256 | ≥32 | ≥256 | 32 | 0.032 | 0.38 | 0.047 | ||
Case 2 (40-yr-old-male) | B1 | 1233 (ST-353 clonal complex) | Blood | 12-09-2016 | ≥256 | ≥32 | 32 | ≥256 | 0,25 | 2 | 0,25 |
B2 | Blood | 02-11-2016 | ≥256 | ≥32 | ≥256 | ≥256 | 0,125 | 2 | 0,25 | ||
B3 | Stool | 18-11-2016 | ≥256 | ≥32 | ≥256 | ≥256 | 0,125 | ≥512 | 8 | ||
B4 | Blood | 30-11-2016 | ≥256 | ≥32 | ≥256 | ≥256 | 0,125 | ≥512 | 8 | ||
B5 | Stool | 14-12-2016 | ≥256 | ≥32 | ≥256 | ≥256 | 0,25 | ≥512 | 32 |
Cutoff values used for strain categorization as resistant (R) were 4 mg/L for erythromycin (Ery), 0.5 mg/L for ciprofloxacin (Cip), 2 mg/L for tetracycline (Tet), 16 mg/L for ampicillin (Amp), and 1 mg/L for ertapenem (Ert) (https://www.sfm-microbiologie.org/wp-content/uploads/2022/05/CASFM2022_V1.0.pdf), and as susceptible (S) <2 mg/L or R > 8 mg/L for meropenem (Mer) and S < 2 mg/L or R > 4 mg/L for imipenem (Imp) (https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_13.0_Breakpoint_Tables.pdf).