TABLE 4.
Characteristics of the 11 ST463 strains
| Strain | Patient |
Sourcea | Department | Beta-lactamases | PBP3 mutation | AmpC upregulation | oprD | Efflux pump upregulation | |
|---|---|---|---|---|---|---|---|---|---|
| Age | Gender | ||||||||
| 1 | 66 | Male | RTI | Surgery, ICU | OXA-486, PDC-8 | F533Lb | No | Gross disruption | Yes (mexZ, mexXY) |
| 2 | 48 | Female | IAI | Surgery, general | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes (mexZ, mexXY) |
| 3 | 74 | Male | RTI | Medicine, ICU | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes (mexZ, mexXY) |
| 4 | 44 | Male | BSI | Medicine, general | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes (mexZ, mexXY) |
| 5 | 72 | Female | UTI | Medicine, ICU | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes (mexZ, mexXY) |
| 6 | 59 | Male | RTI | Medicine, ICU | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes (mexZ, mexXY) |
| 7 | 54 | Male | RTI | Surgery, ICU | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes, (mexZ, mexXY) |
| 8 | 72 | Female | RTI | Emergency room | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes, (mexZ, mexXY) |
| 9 | 56 | Male | RTI | Medicine, ICU | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes, (mexZ, mexXY) |
| 10 | 42 | Female | IAI | Surgery, general | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes, (mexZ, mexXY) |
| 11 | 69 | Female | BSI | Medicine, general | KPC-2, OXA-486, PDC-8 | F533L | No | Gross disruption | Yes, (mexZ, mexXY) |
a
RTI, respiratory tract infection; IAI, intraabdominal tract infection; BSI, bloodstream infection; UTI, urinary tract infection.
b
F533L, a change of F to L at position 533.