FIG 8.

Tsap peptides suppress LTA-stimulated inflammation in vitro and in vivo. The ability of Tsap-1 (A), Tsap-2 (B), and Tsap-3 (C) to neutralize endotoxins at various concentrations is illustrated. TNF-α content in the Tsap-1-treated (D), Tsap-2-treated (E), and Tsap-3-treated (F), LTA-infected inflammation model. IL-6 content in Tsap-1-treated (G), Tsap-2-treated (H), and Tsap-3-treated (I), LTA-infected HeLa cell inflammation models. LTA-mediated lung inflammation in mice (J) and Tsap-1-treated sections (K); the untreated group was used as a control (L).