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. 2023 Jul 20;11(4):e00308-23. doi: 10.1128/spectrum.00308-23

FIG 9.

FIG 9

Tsap-1 exhibits good combined bactericidal effects in vitro and in vivo. Schematic checkerboard diagram showing the results obtained when Tsap-1 (A), Tsap-2 (B), and Tsap-3 (C) were administered in combination with ciprofloxacin. The blue color ranging from light to dark indicates an increase in drug concentration. Survival of mice after S. aureus USA200 injection in the ciprofloxacin, Tsap-1, and combination treatment groups (D). Bacterial load in spleen (E), kidney (F), lung (G), and liver (H) in mice infected with S. aureus USA200 after treatment with ciprofloxacin, Tsap-1, or a combination of the two.