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. 2023 Aug 3;10:1203430. doi: 10.3389/fnut.2023.1203430

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Copyright © 2023 Wang, Ni, Li, Shao, Yong, Lv, Zhang, Fu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Untargeted metabolomics analysis of the metabolites in the diabetic and CH-P treatment groups using the POS model. (A) Principal component analysis score plot showing comparisons of the metabolomic profiles in both groups. (B) Volcano plot showing the differentially accumulated and significantly changed metabolites. (C) The PLS-DA score plot comparing the metabolome profiles in both groups and statistical validation of the PLS-DA model by permutation testing. (D) Hierarchical clustering heatmap of metabolites showing metabolites that significantly differ in abundance between both groups.