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. 2023 Jul 20;133(5):430–443. doi: 10.1161/CIRCRESAHA.123.322629

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© 2023 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — One-micromolar Danicamtiv (Dani) and Omecamtiv Mecarbil (OM) increased ATP binding and decreased ADP release in activated porcine cardiac muscle. A, The cross-bridge detachment rates (k_rel) increased with increasing [MgATP] for the untreated, Dani-treated and OM-treated myocardial strips. Treatment with both Dani and OM decreased k_rel at [MgATP] >0.5 mmol/L (B). Dani and OM decreased ADP release rate (B, k_-ADP) while increasing ATP binding (C, k_+ATP). MgATP concentration at half-maximal detachment rate ([MgATP]₅₀) was lower for both Dani-treated and OM-treated strips (D). Data are from 9 tissue preparations per condition.