TABLE 1.

The difference in structure, surroundings and healing processes between oral mucosa and skin.

	Oral mucosa	Skin	References
Structures	Epithelial and lamina propria, part of the oral mucosa has submucosa	Epidermis, dermis and subcutaneous tissue	Glim et al. (2013)
	Keratinization/Incomplete keratinization	Keratinization	Qin et al. (2017)
	Salivary glands	Hair follicles, sebaceous glands, sweat glands	Glim et al. (2013)
	Thicker epithelium	Relatively thin epithelium	Glim et al. (2013)
	High proliferation rate of basal cells	Low proliferation rate of basal cells	Gibbs and Ponec (2000)
	Relatively high degree of vascularization	Relatively low degree of vascularization	Brand et al. (2014)
Surroundings	Epidermal moistening	Epidermal dryness	Brand et al. (2014)
	Exposure to saliva	Exposure to air	Brand et al. (2014)
	Subjected to chewing force and tension, continuously exposed to bacteria		Dutzan et al. (2017)
Healing process	The oral mucosa has less neovascularization than the skin		Szpaderska et al. (2005)
		Fibroblasts are more responsive to stimulus	Mak et al. (2009)
	Lower inflammation levels		Szpaderska et al. (2003), Chen et al. (2010)
	Saliva contains high levels of healing-promoting histone and growth factors		Brand et al. (2014)
	Oral keratinocytes have a proliferative capacity greater than that of skin keratinocytes		Turabelidze et al. (2014)
	Oral wounds exhibit rapid re-epithelialization		Schrementi et al. (2008)