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. 2023 Aug 7;19(8):e1011274. doi: 10.1371/journal.ppat.1011274

Fig 11. ZIKV infection at 10 dpi shows extensive infection of the chorionic membrane.

Fig 11

(A) A Representative coronal section of gravid uterus evaluated via ISH for ZIKV RNA (pink). Pink tissue/structure names indicate the detection of ZIKV RNA via ISH. The fetal head has been added to this image from a different coronal section. The yellow and red squares outline the areas magnified in (B) and (C), respectively. (B)(C) IF staining for cytokeratin (red) and ZIKV (green) and nuclear DAPI (blue). Colocalization of green and red shows that ZIKV has infected the trophoblasts of the chorionic membrane. (D) H&E stained section corresponding to section shown in (E) depicting ZIKV RNA detected via ISH (pink) in the trophoblast layer (t) of the chorionic membrane. The mesenchymal layer is indicated by m. (F) ZIKV RNA detected via ISH in the peripheral margin of the placental disc. (G) H&E stained section. (H) Full slide evaluated via ISH the black square outlines the portion magnified in (E) and the orange square outlines the portion magnified in (F). The scale bar represents 400 μm in (B), 200 μm in (C)–(G), and 2350 μm in (H).