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. 2023 Aug 3;14:1159829. doi: 10.3389/fphar.2023.1159829

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Copyright © 2023 Chen, Liu, Chen, Zhang, Tao, Chen, Wang, Sun, Wu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JPYZXZ decreased the expression of PD-L1 and exosomal PD-L1 levels in tumor-bearing mice. (A) Representative photographs of tumors. (B) Tumor weights on days 2, 4, 6, 8, 10, 12, 14, 16, and 18. (C) The body weights were detected every 2 days. (D) Representative images of H&E staining of the tumor tissue sections from indicated mice. Upper row: scale bar = 20 μm; lower row: scale bar = 10 μm. (E–J) Expression levels of IL-6/JAK2/STAT3 pathway-related proteins and PD-L1 in the tumor tissues. (K) Exosomal PD-L1 levels in the serum of tumor-bearing mice. Data are represented as the mean ± SEM, n = 5 mice or n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.