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. 2023 Aug 16;20(1):603–613. doi: 10.1080/15476286.2023.2246256

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — The crosstalk between m⁶A modifications and other RNA modifications. (A) FTO plays a role in the demethylation of various RNA modifications, including m⁶A, m⁶Am and m¹A. m¹A-mediated tRNA modifications play an important role in the regulation of translation required for T cell activation, and the function of FTO in this is still unknown. (B) the binding protein YTHDF1 binds m¹A in addition to m⁶A and thus mediates translation initiation. (C) in addition to binding m⁶A, YTHDC1 also has a weak RNA helicase function. There may be crosstalk between multiple RNA modifications, and how m⁶A regulators coordinate their functions in multiple RNA modifications and the roles they play in immune cells need to be further investigated.