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. 2023 Jul 25;101(4):e438–e450. doi: 10.1212/WNL.0000000000207443

Figure 3. Exploratory Subgroup Analysis of the Pooled De-escalations.

Figure 3

Age, disease duration, time since disease activity, the cumulated number of relapses, and the last EDSS were dichotomized according to their medians. Each increased infusion interval was analyzed as an observation unit. The forest plot shows the estimated absolute risks of reactivation at 12 months and their 95% CIs in AQP4+ patients (blue) and in AQP4− patients (red). *An irreversible EDSS value was not available before 15 (10.9%) de-escalations. **The hazard ratios were computed using a Cox proportional-hazards model adjusting for the five variables. Missing EDSS were imputed. ARR = annualized relapse rate; AQP4+ = antiaquaporin 4-IgG antibodies; EDSS = Expanded Disability Status Scale.