Figure 3.

Mutation vulnerability of disease associated genes to various carcinogens. Heatmaps of observed minus expected mutations in disease gene sets for (A) mutations in gene body sequence following chemical treatment in iPSC, (B) mutations in coding sequences following chemical treatment in iPSC, and (C) mutations in 14 human lung cancers from individuals living in highly polluted regions. Significant levels from exact binomial tests. Higher mutation rates: ^*p < 0.05; ^**Bonferroni-adjusted p < 0.05. Lower mutation rates: ^†p < 0.05.