Figure 10. AMPAr Markov chain with three sub-conductance states and two desensitisation levels.

It includes parameters ${\rho }_f^{A\mathbf{}M\mathbf{}P\mathbf{}A}$, ${\rho }_b^{A\mathbf{}M\mathbf{}P\mathbf{}A}$ (binding and unbinding of glutamate) which depend on temperature. Open states are ${\displaystyle O2}$, ${\displaystyle O3}$, and ; closed states are $C\mathbf{}\mathrm{0}$, $C\mathbf{}\mathrm{1}$, $C\mathbf{}\mathrm{2}$, $C\mathbf{}\mathrm{3}$, and $C\mathbf{}\mathrm{4}$; desensitisation states are $D\mathbf{}\mathrm{0}$, $D\mathbf{}\mathrm{1}$, $D\mathbf{}\mathrm{2}$, $D\mathbf{}\mathrm{3}$, and $D\mathbf{}\mathrm{4}$; deep desensitisation states are $D_{\mathrm{2}}\mathbf{}\mathrm{2}$, $D_{\mathrm{2}}\mathbf{}\mathrm{3}$, and $D_{\mathrm{2}}\mathbf{}\mathrm{4}$.