Appendix 1—table 1. Synaptic plasticity protocol parameters.

To fit the data from publications displaying a parameter interval (e.g. 70–100), we used a value within the provided limits. Otherwise, we depict in parentheses the value used to fit to the data. Further information is available in the github code and Appendix 1—table 3. Some of these experiments did not control AP generation following EPSP stimulation: Mizuno et al., 2001, Dudek and Bear, 1992 Dudek and Bear, 1993. We modeled this effect, described below. In addition, Tigaret et al., 2016 used GABA(A)r blockers, which we modelled by setting the GABAr conductance to zero. Also, Mizuno et al., 2001 LTD protocol used a partial NMDA blocker, which we modelled by reducing NMDA conductance by 97%.

Experiment	Paper	Repetitions	Freq (Hz)	Age (days)	Temp. (${}^{\circ }C$)	[Ca2+]o(mM)	[Mg2+]o(mM)
STDP	Tigaret et al., 2016	300	5	56	35	2.5	1.3
STDP	Inglebert et al., 2020	100, positive delays	0.3	21	(30.45)	1.3—3	Ca/1.5
STDP	Inglebert et al., 2020	150, negative delays	0.3	14	30	1.3—3	Ca/1.5
STDP	Meredith et al., 2003	20	0.2	9—45	24—28	2	2
STDP	Wittenberg and Wang, 2006	70—100	5	14—21	(22.5–23)	2	1
pre-burst	Tigaret et al., 2016	300 and 900	3 and 5	56	35	2.5	1.3
FDP	Dudek and Bear, 1992	900	1—50	35	35	2.5	1.5
FDP	Dudek and Bear, 1993	900	1	7—35	35	2.5	1.5
TBS	Dudek and Bear, 1993	3—4 (5) epochs	4Pre at 100 Hz, 10 x at 5 Hz	6, 14 and 17	35	2.5	1.5
LFS	Mizuno et al., 2001	1—600	1	12—28	(26.5–31)	2.4	0