Table 3.

CASP quality assessment of the reviewed randomized controlled trial papers.

	Section A: Are the Results of the Trial Valid?						Section B: What are the Results?			Section C: Will the Results Help Locally?
Authors, Year	Item 1	Item 2	Item 3	Item 4	Item 5	Item 6	Item 7	Item 8	Item 9	Item 10	Item 11	Total Quality Score (0–11)
Uemura et al. (2019)	Yes	Yes	Yes	No	Yes	Yes	Treatment improved statistically	Yes	No	Yes	Yes	9
Stevens et al. (2019)	Yes	Yes	Yes	Yes	Yes	Yes	Treatment improved statistically	Yes	No	Yes	Yes	10
Khine et al. (2020)	Yes	Yes	Yes	No	No	Yes	Treatment improved statistically	Yes	No	Yes	Yes	8

CASP, Critical Appraisal Skills Program. Item 1: Was the study issue is clearly focused?; Item 2: Was the assignment of patients to treatments randomized?; Item 3: Were all of the patients who entered the trial properly accounted for at its conclusion?; Item 4: Were patients, health workers and study personnel “blind” to treatment?; Item 5: Were the groups similar at the start of trial; Item 6: Aside from the experimental intervention, were the groups treated equally?; Item7: How large was the treatment effect?; Item 8:How precise was the estimate of the treatment effect?; Item 9: Can the results be applied to the local population, on in your context?; Item 10: Were all clinically important outcomes considered?; Item 11: Are the benefits worth the harms and costs?