Table 3.

Effect of the crude extract and solvent fractions of S. macrosolen on the parasite level, parasite suppression, and MST of P. berghei-infected mice in the 4-day suppressive test.

Group	Doses (mg/kg)	% parasitemia (M ± SEM)	% suppression	Mean survival time (days)
DW	10 ml/kg	54.82 ± 2.97	0	7.17 ± 0.31
CQ	25	0.00 ± 0.00a3	100a3	30.00 ± 0.00a3
SM	100	46.97 ± 0.97b3e2	14.33b3e2	7.67 ± 0.21
SM	200	42.78 ± 2.44a2b3e1	21.97a2b3e1	8.33 ± 0.33a1
SM	400	33.32 ± 2.08a3b3c2d1	39.23a3b3c2d1	8.67 ± 0.33a2
AF	100	38.48 ± 5.66a1b3	29.81a1b3	8.33 ± 0.33b3
AF	200	32.63 ± 3.23a2b3	40.48a2b3	9.00 ± 0.37a2b3
AF	400	31.21 ± 4.02a2b3	43.07a2b3	9.33 ± 0.42a2b3
TE	10 ml/kg	48.85 ± 7.34	0	6.67 ± 0.33
CQ	25	0.29 ± 0.12a3	99.41a3	30.00 ± 0.00a3
CF	100	41.79 ± 3.91b3	14.46b3	8.00 ± 0.52b3
CF	200	39.71 ± 4.10b3	18.72b3	8.17 ± 0.40b3
CF	400	30.10 ± 3.90a1b2	38.38a1b2	8.50 ± 0.34a1b3
EF	100	35.20 ± 3.19b3	27.95b3	8.50 ± 0.34a1b3
EF	200	29.46 ± 3.72a1b2	39.70a1b2	8.67 ± 0.42a2b3
EF	400	28.03 ± 4.61a1b2	42.61a1b2	9.00 ± 0.52a2b3

Data are expressed as mean ± SEM (n = 6); AF = aqueous fraction; CQ = chloroquine; DW = distilled water (negative control for the crude extract and AF fraction); TE = 2% Tween 80 (negative control for CF and EF fractions); CF = chloroform fraction; EF = ethyl acetate fraction; a = compared to the negative control; b = compared to the positive control; c = compared to 100 mg/kg crude extract; d = compared to 200 mg/kg crude extract; e = compared to 400 mg/kg crude extract; SM = Silene macrosolen; 1 = P < 0.05; 2 = P < 0.01; 3 = P < 0.001.