Table 5.
Effect of the crude extract of S. macrosolen on the parasite level, parasite suppression, and mean survival time of P. berghei-infected mice in the prophylactic test.
| Group | Doses (mg/kg) | % parasitemia (M ± SEM) | % suppression | Mean survival time (days) |
|---|---|---|---|---|
| DW | 10 ml/kg | 55.71 ± 1.14 | 0 | 6.67 ± 0.33 |
| CQ | 25 | 0.38 ± 0.14a2 | 99.32a2 | 29.17 ± 0.83a2 |
| SM | 100 | 48.75 ± 4.89b2 | 12.48b2 | 7.33 ± 0.21b2 |
| SM | 200 | 43.88 ± 5.59b2 | 21.23b2 | 7.50 ± 0.22b2 |
| SM | 400 | 38.43 ± 3.93a1b2 | 31.02a1b2 | 8.33 ± 0.21b2 |
Data are expressed as mean ± SEM (n = 6); CQ = chloroquine; DW = distilled water; SM = Silene macrosolen; a = compared to the negative control; b = compared to the positive control 1 = P < 0.05; 2 = P < 0.001.