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. 2023 Jun 29;3(8):100349. doi: 10.1016/j.xgen.2023.100349

Figure 4.

Figure 4

Hypogonadism and gametogenesis defects in both sexes of Fancm-deficient mice

(A) Testes from B6.Fancm+/+ (left) and B6.FancmΔ2/Δ2 (right) mice. Scale bar, 5 mm.

(B) Six- to 14-week-old testes weights were lower in the mutants in all strains. Gray bars indicate mean ± SD.

(C) Quantification of daily sperm production. Gray bars indicate mean ± SD.

(D and E) Total sperm motility (D) and sperm progressive motility (E) were assessed with computer-assisted sperm analysis from 10-week-old mice. Gray bars indicate mean ± SD.

(F) Ovary weights were quantified across the three strains used from 5-week or older mice. Gray bars indicate mean ± SD.

(G) F1 females were superovulated and Fancm-deficient mice produced fewer oocytes. Gray bars indicate mean ± SD. Five mice per genotype; ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, and ∗∗∗∗p ≤ 0.0001.