Fig. 7. Twins can be used for differential feature detection.

An example of two regions along chromosome 2 in neural progenitor cells before and after CTCF degradation. The Twins distance quantifies the level of change in the region here the embedding distances are presented as mean values ± the 95% confidence interval. Using this we can apply our learnt Twins filters to the Hi-C maps. These filters accentuate features of interest which can then be found by thresholding followed by isolation and the application of a convex hull transformation.