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. 2023 Aug 18;13(1):127. doi: 10.1038/s41408-023-00895-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pre-leukapheresis (pre-leuk) and pre- lymphodepletion chemotherapy (pre-LD) coronal fused PET/CT (left) and maximum projection image (right) PET/CT imaging and total tumor volumetric analysis for two patients. The first patient A, B had both increasing extranodal metabolic tumor volume (MTV) and increasing total lesion glycolysis (TLG) of the largest lesion (risk score 2) from pre-leuk A to pre-LD B, and experienced PD and death after CAR-T infusion. The second patient C, D had neither risk factor (risk score 0), is alive and without progression at last follow-up, despite having higher MTV and TLG at each individual time point compared to the first patient.