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. 2023 Aug 17;222(10):e202112143. doi: 10.1083/jcb.202112143

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© 2023 Jones et al.

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Figure 2. — Localization of Bazooka and Par-6 in larval brain NSCs expressing kinase-inactive aPKCs. (A) Localization of Par-6 and Bazooka (Baz) in metaphase larval brain NSCs expressing HA-tagged aPKC D388A or aPKC K293W. Nucleic acids are shown with DAPI. Scale bar is 5 µm. (B and C) Gardner–Altman estimation plots of the effect of expressing aPKC D388A or aPKC K293W on Par-6 (B) or Baz (C) cortical localization and polarity. Apical cortical to cytoplasmic or basal cortical signal intensities of cortical and cytoplasmic signals are shown for individual metaphase NSCs expressing either HA-WT or HA-D388A or HA-K293W aPKC. The error bar in the upper graphs represents one standard deviation (gap is mean); the error bar in lower graphs represents bootstrap 95% confidence interval; n = 16 (from three distinct larval brains), 6 (3), 4 (3) for WT, K293W, D388A, respectively (Par-6) and 16, 6, 4 for Baz.