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. 2023 Aug 3;14:1188750. doi: 10.3389/fimmu.2023.1188750

Figure 1.

Figure 1

The IL-10/IL-10R Signaling pathway. IL-10 binding to its heterodimeric receptor leads to the phosphorylation of STAT3 by JAK1 and Tyk2. Upon phosphorylation, STAT3 translocates to the nucleus where it binds to STAT3-binding elements and activates the transcription of target genes. STAT3 is responsible for activating the transcription of several IL-10 responsive genes including SOCS3, Bcl3, and Ddit4. Tyk2, Tyrosine kinase 2; JAK1, Janus kinase 1; STAT3, Signal transducer and activator of transcription 3; SOCS3, Suppressor of cytokine signaling 3; DDIT4, DNA damage-inducible transcript 4.