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. 2023 Aug 3;14:1188750. doi: 10.3389/fimmu.2023.1188750

Figure 2.

Figure 2

Environmental influences on IL-10-producing B cells. (A) Dietary patterns influence gut microbiota composition. A healthy microbiota and/or its associated diet-derived metabolites can promote the development of IL-10 producing commensal-reactive B cells and IgA+ plasma cells. (B) UV exposure from sunlight, which is influenced by geographical location, changes Vitamin D availability that upon metabolism promotes IL-10 production by lymphocytes. (C) EBV latently infected B cells produce viral homologs of IL-10 that compete with endogenous IL-10 for IL10R binding. Viral IL-10 homologues are less efficient than endogenous IL-10 at triggering downstream signaling.