TABLE 2.

Oxygen-carrying nanoparticles for tumor reoxygenation to enhance the antitumor.

Design	Combined treatment	Effectiveness	Ref
Physical dissolution of oxygen Lipid-stabilized PFC nanoemulsion and carbogen	RT	Carbogen alone decreased hypoxia levels substantially and conferred a smaller but not statistically significant survival advantage over and above radiation alone	Xiang et al. (2019)
LIP(IR780 and PFH)	PDT	tumor growth inhibition in Oxy-PDT mice treated with a low photosensitizer dosage and 20-s laser irradiation, whereas traditional PDT showed negligible tumour inhibition	Cheng et al. (2015)
polyethylene glycol (PEG) stabilized perfluorocarbon	RT	Improve tumor oxygenation and concentrate radiation energy in tumor regions to enhance the X-ray-induced DNA damages	Song et al. (2017)
(PFC) nano-droplets decorated with TaOx nanoparticles
(TaOx@PFC-PEG)
The PFC nanoliposomes (FI@Lip) and biocompatible NO donor S-nitrosated human serum albumin (HSA-SNO)	PDT	This combination strategy of FI@Lip and HSA-SNO obviously relieved intracellular hypoxia and decreased GSH to increase more toxic 1O2 generation for PDT enhancement	Alizadeh et al. (2019)
PFOB nanocapsules coated with PEGylated gold nanoshell	PDT	PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as effi cient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model	Ke et al. (2014)