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. 2023 Aug 11;4(8):100817. doi: 10.1016/j.patter.2023.100817

Figure 4.

Figure 4

Interrogation of VAE using ridge regression in portal hepatocyte response prediction

(A) Schematic of calculation of latent dimension weights using ridge regression.

(B) Bar plot of top 20 genes with the highest scVIDR genes scores.

(C) Enrichr analysis of the top 100 genes with respect to the scVIDR gene scores. Bar plot of adjusted p values from statistically significant (adjusted p value < 0.05) enriched pathways from the WikiPathways 2019 Mouse Database.

(D) PCA projection of single-cell expression data colored by log dose and fatty acid oxidation pathway score.

(E) Logistic fit of median pathway score for each dose value. MAE, mean absolute error.