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. 2023 Aug 3;14:1161901. doi: 10.3389/fimmu.2023.1161901

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Copyright © 2023 Medina, Murison, Smith, Kinker, Chakravarthy, Vitiello, Turpin, Shen, Yau, Sarmento, Faubion, Lupien, Silverberg, Arrowsmith and De Carvalho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of cytotoxic CD4 T cells in additional scRNA-seq datasets. (A, B) Identification of CD4conv T cells in colonic mucosa sample of patients with active UC (n= 195 cells, Mitsialis et al., 2020 [32)] and inflamed ileum samples of CD patients [n= 805 cells, Martin et al., 2019 (33)]. (C, D) Expression of cytotoxicity-related genes by CD4conv T cells in each dataset. Cells are ordered according to their cytotoxic scores, as shown in the lower panel. (E, F) Density plots showing the expression of Th1 and Th17 gene signatures by cells in C0-C2. Shown are both classical signatures (Th1: TNF, STAT1, STAT4, CXCR3 and IFNG; Th17: CCR6, STAT3, RORA, IL17A, RORC) as well as those derived from the DICEdb populations.