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. 2023 Jul 10;94:104701. doi: 10.1016/j.ebiom.2023.104701

Fig. 4.

Fig. 4

Lack of evolution of paramagnetic rim lesions after anti-CD20 treatment. Representative 3D T2∗-weighted magnitude and unwrapped phase MRI images showing paramagnetic rim lesions (PRL) with persistent paramagnetic rims in (a) a 31-year-old with PPMS followed for 39 months, and (b) a 32-year-old with PPMS followed for 40 months, after treatment initiation. In (b), red and yellow arrows delineate two distinct PRL. Abbreviations: MRI, Magnetic resonance imaging; PPMS, Primary progressive MS; PRL, Paramagnetic rim lesions; QSM, Quantitative susceptibility mapping; anti-CD20, anti-CD20 treatment.