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. 2023 Jul 10;94:104701. doi: 10.1016/j.ebiom.2023.104701

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 5 — Lack of change in lesion volume and susceptibility in paramagnetic vs non-paramagnetic rim lesions. Paramagnetic rim lesions (PRL) and non-PRL average adjusted log-lesion volume over time (a) and magnetic susceptibility, derived from quantitative susceptibility mapping (QSM) (b) in treated and untreated cases. The average log-lesion volume and susceptibility were higher in PRL when compared with non-PRL (multivariable linear mixed model, p < 0.0001). There was no significant treatment effect for PRL or non-PRL average adjusted log-lesion volume (multivariable linear mixed model, p = 0.68). Average susceptibility slightly decreased over time in both treated and untreated non-PRL (multivariable linear mixed model, p < 0.0001 and p = 0.006, respectively) but not in treated and untreated PRL (multivariable linear mixed model, p = 0.18). Abbreviations: PRL, paramagnetic rim lesions; treated/untreated, treated/untreated with anti-CD20 antibody therapy; ppm, parts per million.