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. 2023 Aug 3;145(32):17632–17642. doi: 10.1021/jacs.3c03338

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Imaging of S. aureus in vertebral discitis-osteomyelitis (VDO) rat models and A. baumannii in a myositis mouse model using [¹⁸F]FSK. (A) Optical tomography image of a rat tail showing the bioluminescent signal from S. aureus Xen29 inoculation. (B) Computed tomography study performed at 10 days highlights the similarity between rodent and human discitis osteomyelitis. (C) PET/CT imaging of S. aureus Xen29 vertebral discitis-osteomyelitis (VDO) in rat (N = 5) with [¹⁸F]FSK. (D) ROI analysis showing increased signal in segments inoculated with live bacteria versus background (P < 0.0001). (E) PET/CT imaging of A. baumannii myositis in mice (N = 6) with [¹⁸F]FSK. The red arrows indicate the site of inoculation with live bacteria, while the white arrows correspond to heat-killed bacteria. (F) ROI analysis showing an increased signal in infected muscle versus inflammation (P < 0.0001).