Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 18;21:554. doi: 10.1186/s12967-023-04392-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Time-course RNA-seq analysis of colonic tissues from the fibrosis mouse model. A Significant gene expression patterns identified by the STEM software; all expression patterns follow the timeline of Control (Ctrl), Inflammation (TNBS-4W), and Fibrosis (TNBS-6W). B KEGG enrichment results (mainly including signaling and metabolism-related pathways) of Pattern1 and Pattern2 (P < 0.05), in which Gene Ratio indicates the proportion of DEGs enriched in each pathway to the total number of DEGs, the size of the circle represents the number of genes enriched in the pathway, and the color of the circle represents the significance of enrichment. C The top20 metabolism-related biological processes in Pattern1 (P < 0.05, ranked by the number of DEGs in each enriched term). D GO enrichment results for terms related to lipid metabolic processes, wherein the size of the circles represents the number of DEGs in each enriched term and color of the circles represents the significance of enrichment (P < 0.05). E The top20 signaling-related biological processes in Pattern1 (P < 0.05, ranked by the number of DEGs in each enriched term). GO enrichment results are presented as circle diagrams: the first circle (from outside to inside) represents the GO term, and outer circle represents the coordinate scale of the number of genes; second circle represents the number of DEGs annotated to the GO entry, and color represents the -log10 (P value) of the enrichment analysis; third circle represents the number of differentially up-regulated DEGs in the term; and fourth circle represents the percentage of enrichment factors. n = 5 per group. STEM Short Time-series Expression Miner, KEGG Kyoto Encyclopedia of Genes and Genomes; GO Gene Ontology, DEGs differentially expressed genes