Figure 1.

PRMT1 is strongly associated with poor prognosis of MM patients. Expression of PRMTs in MM cell line (A) and primary MM patient cells (B). (C) Expression of PRMT1 in newly diagnosed patient (NDMM) and relapsed/refractory patients (RRMM). TPM+1: transcripts per million. Data are shown as mean value. P values were calculated using one-way Anova test (compared to PRMT1 group) are shown in the graph or as ****P<0.0001 and ***P<0.001. (D) MM patients were divided into 2 groups based on expression of PRMT1: low expression (1^st Quartile) and high expression (4^th Quartile). Progression-free survival (middle) and overall survival (right) of patients with different expression level of PRMT1. P-values were derived from log-rank test.