Table 1.
The detailed characteristics of the included studies.
| Study ID | Gender (male/female) | Sample size (I/C) | Age (mean or range, years) | Course (mean or range, days) | Intervention vs. control | Intervention details | Control details | Outcomes |
|---|---|---|---|---|---|---|---|---|
| Chen (20) | 67/43 | I, 55 C, 55 |
I, 1.07 ± 0.40 C, 1.04 ± 0.36 |
I, 14.94 ± 2.43 C, 14.68 ± 1.96 |
CBMMA + MP vs. MP | CMBBA, 24 h/time, QD | NR | ① ④ |
| Qian (21) | 31/29 | I, 30 C, 30 |
I, 4.39 ± 1.48 C, 4.31 ± 1.32 |
I, 4.01 ± 1.29 C, 4.03 ± 1.23 |
CBMMA + MP vs. MP | CMBBA, 3∼6 h/time, BID, + Control. Course = 3 day |
MP, <1 year old, 1/3 pack/time, 1–2 years old, 1/3–2/3 pack/time, >2 years old, 2/3–1 pack/time. TID. Course = 3 day |
① ④ |
| Gui (22) | 73/63 | I, 68 C, 68 |
I, 1.69 ± 0.33 C, 1.63 ± 0.31 |
NR | CMBBA vs. MP | CMBBA, QD. Course = 5 day |
MP, 1 pack/time, <1 year old, QD, ≥1 year old, BID, Course = 5 day | ① ② |
| Zhou (23) | 78/42 | I, 60 C, 60 |
I, 1.31 ± 0.34 C, 1.3 ± 0.43 |
NR | CBMMA + MP + M vs. MP + M | CMBBA, 2–6 h/time, BID, +Control. Course = 3 day |
M, 1 pack/time, BID, MP, 1/3 pack/time, TID, Course = 3 day | ① ② |
| Huang (24) | 51/45 | I, 48 C, 48 |
I, 0.58–3 C, 0.5–3 |
I, 0.29–3 C, 0.25–2 |
CBMMP + MP vs. MP | CMBBA, 10 h/time, BID, + Control. Course = 3 day |
MP, <1 year old, 1/3 pack/time, TID, 1–2 years old, 1/3∼2/3 pack/time, TID, >2 years old, 2/3–1 pack/time, TID. Course = 3 day |
① ② ③ |
| Chen (25) | 65/55 | I, 60 C, 60 |
I, 1.48 C, 1.52 |
I, 2.55 C, 2.67 |
CMBBA + MP vs. MP + M | CMBBA, 3 h/time, QD, Course = 3 day | M, <1 year old, 1/2 pack/time, 1–3 years old, 1 pack/time, MP: NR. TID. Course = 3 day |
① |
| Yue (26) | 152/128 | I, 140 C, 140 |
I, 1.19 ± 0.56 C, 1.16 ± 0.58 |
I, 7.6 ± 1.0 C, 7.4 ± 0.8 |
CMBBA vs. MP + M | CMBBA, 4–6 h/time, QD, Course = 5 day | NR | ① |
| Huang (27) | 46/36 | I, 41 C, 41 |
I, 0.85 ± 0.19 C, 0.9 ± 0.20 |
<3 | CMBBA + MP vs. MP | CMBBA, 12–24 h/time | NR | ① ② ③ ④ |
| Ren (28) | 55/33 | I, 44 C, 44 |
I, 1 ± 0.38 C, 1 ± 0.08 |
NR | CMBBA + MP + AI vs. MP + AI | CMBBA, +Control. Course = 2 day |
MP, <1 year old, 1 pack/time, >1 year old, 2 pack/time. BID. AI, NR. Course = 2 day |
① ④ |
| Tan (29) | 27/33 | I, 30 C, 30 |
2.3 | <3 | CMBBA + MP + M vs. MP + M | CMBBA, 24 h/time, QD, +Control. Course = 3 day |
MP, <1 year old, 1/3 pack/time, 1–2 years old, 1/3–2/3 pack/time, >2 years old, 2/3–1 pack/day. TID. M, <1 year old, 1/6 pack/time, 1–5 years old, 1/3 pack/time. TID. Course = 3 day |
① |
| Wu (30) | 68/52 | I, 60 C, 60 |
2.5 | 2–6 | CMBBA + M + AI vs. MP + AI | CMBBA, BID, +Control. Course = 3 day |
MP, <1 year old, 1/3 pack/time, 1–3 years old, 1/2 pack/time, >3 years old, 1 pack/time. TID. AI, NR. Course = 3 day |
① |
| Xin (31) | NR | I, 80 C, 80 |
0.08–3 | 1–30 | CBMMP + MP vs. MP | CMBBA, 48 h/time, +Control. Course = 6 day | MP, <1 year old, 1/3 pack/time, 1–3 years old, 1/2 pack/time. The first dose is doubled. TID. Course = 3 day |
① |
| Wang (32) | 98/94 | I, 96 C, 96 |
0.5–0.75 (30) 0.83–0.92 (82) 1–2 (80) |
NR | CMBBA + MP + AI vs. MP + AI | CMBBA, QD, +Control. Course = 3 day | AI, Ribavirin. Antibiotic. MP: NR. Course = 3 day |
① |
| Dong (33) | NR | I, 96 C, 90 |
1.8 | 1.6 | CMBBA + MP + M vs. MP + M | CMBBA, 8 h/time, BID, +Control. Course = 3 day |
NR | ① ② ③ ④ |
| Li (34) | 151/103 | I, 127 C, 127 |
0.25–1 (68) 1–3 (152) 4–5 (34) |
≤14 | CBMMP + MP + M vs. MP + M | CMBBA, QD, 24 h/time, +Control. Course = 3 day |
MP, <6 kg, 1/3 pack/time, 6–15 kg, 1/2 pack/time, >15 kg, 1 pack/time. M: NR. TID. Course = 3 day |
① |
| Shi (35) | 60/40 | I, 50 C, 50 |
I, 0.3–5 C, 0.2–6 |
NR | CMBBA + MP + AI vs. MP + AI | CMBBA, QD, +Control. Course = 3 day | AI, Ribavirin, 10 mg/(kg·day). Amoxicillin. MP, 1 pack/time TID. Course = 3 day |
① ② ③ |
| Zhang (36) | NR | I, 52 C, 52 |
NR | <2 | CMBBA + MP + M vs. MP + M. | CMBBA, 20 h/time, QD, +Control. Course = 3 day |
NR | ① |
| Zhang (37) | NR | I, 30 C, 30 |
0.5–3 | <14 | CBMMA vs. MP | CMBBA, QD, 2–4 h/time. Course = 5 day |
MP, 0.5–1 year old, 1 pack/time, 1–2 years old, 1.5 pack/time, 2–3 years old, 2 pack/time. TID. Course = 5 day |
① |
| Zhou (38) | 37/31 | I, 36 C, 32 |
I, 0.90 C, 0.91 |
NR | CMBBA vs. MP + M + AI. | CMBBA, 24 h/time, QD, Course = 5 day | AI, Ribavirin | ① |
| Li (39) | 74/46 | I, 60 C, 60 |
I, 0–0.5 (6) 0.5–1 (22) 1–2 (32) C, 0–0.5 (9) 0.5–1 (22) 1–2 (29) |
I, 0–3 (39) ≥3 (21) C, 0–3 (38) ≥3 (22) |
CMBBA vs. MP + AI | CMBBA, QD, Course = 3 day | MP, 1/3–1/2 pack/time, TID. AI, Moroxydine, 5 mg–10 mg/kg/day, TID. Course = 3 day | ① |
| Luo (40) | 76/52 | I, 64 C, 64 |
I, 1.01 ± 0.75 C, 1.05 ± 0.82 |
I, 1–2 (21) 3–4 (36) >5 (7) C, 1–2 (27) 3–4 (36) >5 (7) |
CMBBA vs. MP + M. | CMBBA, 24 h/time, QD, Course = 3 day | M, <2 years old, 1 pack/time, >2 years old, 1–2 pack/time. QD or BID. MP, <1 year old, 1/3 pack/time, 1–2 years old, 1/3–2/3 pack/time, >2 years old, 2/3–1 pack/time. TID. Course = 3 day |
① |
| Chen (41) | 85/61 | I, 76 C, 70 |
0.25–2 | >2 | CMBBA + MP + M vs.MP + M | CMBBA, 24 h/time, QD, +Control. Course = 3 day |
MP, TID. M, TID. Course = 3 day |
① |
| Yang (42) | 46/24 | I, 35 C, 35 |
I, 1.01 ± 0.78 C, 1.04 ± 0.82 |
I, ≤2 (17) 3–5 (8) 5–10 (7) 11–30 (3) C, ≤2 (19) 3–5 (7) 5–10 (7) 11–30 (2) |
CMBBA vs. MP | CMBBA, 6 h/time, QD, Course = 3 day | NR | ① |
| Zhu (43) | 37/51 | I, 48 C, 40 |
I, 3.8 ± 0.41 C, 3.92 ± 0.38 |
I, 1.15–7.00 C, 1.20–6.85 |
CMBBA + MP vs. MP | CMBBA, QD, +Control, Course = 6 day | MP, TID. Course = 6 day |
① |
| Fu (44) | NR | I, 74 C, 72 |
0.25–3 | <3 | CMBBA vs. MP + M. | CMBBA, 12–24 h/time, Course = 3 day | MP, <1 year old, 1/3 pack/time, 1–2 years old, 2/3 pack/time. The first dose is doubled. TID. M, <1 year old, 1/2 pack/time, 1–2 years old, 1 pack/time. BID. Course = 3 day |
① |
| Li (45) | 64/52 | I, 64 C, 52 |
I, 1.5 C, 1.42 |
I, 2.7 C, 2.8 |
CBMMP + MP vs. MP | CMBBA, QD. + Control. Course = 3–5 day |
MP, 0–1 years old, 1/3 pack/time, 1–2 years old, 1/2–2/3 pack/time, 2∼3 years old, 5/6–1 pack/time. The first dose is doubled. TID. Course = 3–5 |
① ② ④ |
| Wang (46) | 110/100 | I, 112 C, 98 |
I, 0–1 (78) >1 (34) C, 0–1 (71) >1 (27) |
NR | CMBBA vs. MP | CMBBA, 48 h/time. Course = 3 day |
MP, <1 year old, 1 pack/time, 1–2 years old, 1–2 pack/time. QD. Course = 3 day |
① |
| Zheng (47) | 128/72 | I, 100 C, 100 |
I, 1.0 C, 1.1 |
I, 1–2 (35) 3–4 (50) >5 (15) C, 1–2 (38) 3–4 (54) >5 (8) |
CMBBA vs. MP + M + AI | CMBBA, 24 h/time, QD, Course = 5 day | AI, Ribavirin. Antibiotic. Course = 5 day |
① |
| Zhou (48) | 128/72 | I, 100 C, 100 |
I, 1.01 ± 0.75 C, 1.05 ± 0.82 |
I, 1–2 (35) 3–4 (50) >5 (15) C, 1–2 (38) 3–4 (54) >5 (8) |
CMBBA vs. MP + M + AI | CMBBA, 24 h/time, QD, Course = 5 day | AI, Ribavirin. Course = 5 day |
① |
| Chen (49) | 75/55 | I, 70 C, 60 |
I, 0.5–1 (42) 1–2 (28) C, 0.5–1 (35) 1–2 (25) |
I, 1–3 C, 1–4 |
CBMMA + MP + M vs. MP + M | CMBBA, 12–24 h/time, +Control. Course = 3 day |
NR | ① ② |
| Zhao (50) | 64/52 | I, 64 C, 52 |
I, 1.5 C, 1.42 |
I, 2.7 C, 2.8 |
CMBBA + MP vs. MP | CMBBA, QD, + Control, Course = 3–5 day | MP, 0–1 years old, 1/3 pack/time, 1–2 years old, 1/2–2/3 pack/time, 2–3 years old, 5/6–1 pack/time. The first dose is doubled. TID. Course = 3–5 day |
① ② ④ |
| Zhou (51) | 77/67 | I, 96 C, 48 |
I, 0.79 C, 0.83 |
NR | CBMMA vs. MP | CMBBA, QD, Course = 3 day | MP, <1 year old, 1 pack/time, 1–3 years old, 1.5 pack/time. TID. Course = 3day |
① |
| Tan (52) | 188/92 | I, 153 C, 127 |
I, 0.7 ± 0.23 C, 0.74 ± 0.23 |
I, 2.1 ± 0.64 C, 2.3 ± 0. 69 |
CMBBA + MP vs. MP | CMBBA, 24 h/time, QD, +Control. Course = 3 day |
NR | ① |
I, intervention group; C, control group; NM, not mentioned; qd, one time a day; bid, two times a day; tid, three times a day. The specific meaning of treatment column are, CMBBA, Chinese medicine belly button application; MP, montmorillonite powder; M, microecologics; AI, anti-infectives. ① Clinical effectiveness, ② time to diarrheal disappearance, ③ the recovery time of dehydration, ④ adverse events. Montmorillonite powder every pack, 3 g. Microecologics every pack, 1 g.