TABLE 3.
Results of coupling analysis among multiple region-of-interest and multiple frequency bands between healthy controls, mild cognitive impairment and Alzheimer’s disease.
| Krusal–Wails | Between-group differences | Krusal–Wails | Between-group differences | |||||||
| HC-MCI | MCI-AD | HC-AD | HC-MCI | MCI-AD | HC-AD | |||||
| Delta-theta | Left frontal | H = 9.239, p = 0.040 | – | 0.006 | – | Right frontal | H = 0.665, p = 0.819 | – | – | – |
| Left temporal | H = 1.269, p = 0.787 | – | – | – | Right temporal | H = 2.255, p = 0.787 | – | – | – | |
| Left parietal | H = 1.055, p = 0.787 | – | – | – | Right parietal | H = 10.203, p = 0.040 | – | – | 0.007 | |
| Left occipital | H = 0.366, p = 0.833 | – | – | – | Right occipital | H = 1.373, p = 0.787 | – | – | – | |
| Delta-alpha | Left frontal | H = 14.567, p = 0.004 | – | 0.034 | 0.001 | Right frontal | H = 10.546, p = 0.010 | – | 0.042 | 0.006 |
| Left temporal | H = 10.241, p = 0.010 | – | – | 0.007 | Right temporal | H = 5.432, p = 0.066 | – | – | – | |
| Left parietal | H = 13.922, p = 0.004 | – | – | <0.001 | Right parietal | H = 11.581, p = 0.008 | – | – | 0.002 | |
| Left occipital | H = 8.035, p = 0.023 | – | 0.034 | 0.042 | Right occipital | H = 7.821, p = 0.023 | – | – | 0.014 | |
| Delta-beta | Left frontal | H = 2.661, p = 0.422 | – | – | – | Right frontal | H = 3.904, p = 0.284 | – | – | – |
| Left temporal | H = 0.988, p = 0.610 | – | – | – | Right temporal | H = 1.455, p = 0.552 | – | – | – | |
| Left parietal | H = 4.091, p = 0.284 | – | – | – | Right parietal | H = 4.894, p = 0.284 | – | – | – | |
| Left occipital | H = 4.099, p = 0.284 | – | – | – | Right occipital | H = 1.643, p = 0.552 | – | – | – | |
| Delta-gamma | Left frontal | H = 7.507, p = 0.031 | – | – | 0.030 | Right frontal | H = 5.927, p = 0.059 | – | – | – |
| Left temporal | H = 19.193, p < 0.001 | – | 0.005 | <0.001 | Right temporal | H = 19.029, p < 0.001 | 0.022 | – | <0.001 | |
| Left parietal | H = 11.647, p = 0.006 | – | 0.023 | 0.004 | Right parietal | H = 18.077, p < 0.001 | 0.005 | – | <0.001 | |
| Left occipital | H = 5.484, p = 0.064 | – | – | – | Right occipital | H = 7.691, p = 0.031 | – | – | 0.019 | |
| Theta-alpha | Left frontal | H = 10.009, p = 0.197 | – | – | – | Right frontal | H = 9.345, p = 0.224 | – | – | – |
| Left temporal | H = 1.120, p = 0.467 | – | – | – | Right temporal | H = 3.100, p = 0.224 | – | – | – | |
| Left parietal | H = 2.793, p = 0.197 | – | – | – | Right parietal | H = 6.836, p = 0.128 | – | – | – | |
| Left occipital | H = 3.558, p = 0.224 | – | – | – | Right occipital | H = 3.405, p = 0.224 | – | – | – | |
| Theta-beta | Left frontal | H = 0.198, p = 0.906 | – | – | – | Right frontal | H = 1.130, p = 0.855 | – | – | – |
| Left temporal | H = 1.688, p = 0.855 | – | – | – | Right temporal | H = 0.710, p = 0.855 | – | – | – | |
| Left parietal | H = 1.505, p = 0.855 | – | – | – | Right parietal | H = 3.524, p = 0.855 | – | – | – | |
| Left occipital | H = 1.856, p = 0.855 | – | – | – | Right occipital | H = 0.581, p = 0.855 | – | – | – | |
| Theta-gamma | Left frontal | H = 7.143, p = 0.045 | – | – | 0.030 | Right frontal | H = 2.146, p = 0.342 | – | – | – |
| Left temporal | H = 13.336, p = 0.004 | – | 0.038 | 0.002 | Right temporal | H = 19.001, p < 0.001 | 0.049 | 0.038 | <0.001 | |
| Left parietal | H = 8.601, p = 0.028 | – | 0.034 | 0.026 | Right parietal | H = 12.258, p = 0.005 | 0.029 | – | 0.004 | |
| Left occipital | H = 3.942, p = 0.159 | – | – | – | Right occipital | H = 5.630, p = 0.080 | – | – | – | |
| Alpha-beta | Left frontal | H = 1.617, p = 0.560 | – | – | – | Right frontal | H = 2.880, p = 0.560 | – | – | – |
| Left temporal | H = 1.159, p = 0.560 | – | – | – | Right parietal | H = 3.432, p = 0.560 | – | – | – | |
| Left parietal | H = 4.794, p = 0.560 | – | – | – | Right parietal | H = 3.432, p = 0.560 | – | – | – | |
| Left occipital | H = 1.380, p = 0.560 | – | – | – | Right occipital | H = 2.545, p = 0.560 | – | – | – | |
| Alpha-gamma | Left frontal | H = 16.709, p < 0.001 | – | 0.024 | <0.001 | Right frontal | H = 7.873, p = 0.022 | – | – | 0.028 |
| Left temporal | H = 11.723, p = 0.005 | – | 0.020 | 0.005 | Right temporal | H = 9.514, p = 0.012 | – | – | 0.006 | |
| Left parietal | H = 16.325, p < 0.001 | – | 0.014 | <0.001 | Right parietal | H = 17.449, p < 0.001 | – | 0.026 | <0.001 | |
| Left occipital | H = 7.620, p = 0.022 | – | 0.039 | – | Right occipital | H = 15.520, p < 0.001 | – | – | <0.001 | |
| Beta-gamma | Left frontal | H = 13.112, p = 0.001 | – | 0.007 | 0.005 | Right frontal | H = 8.856, p = 0.012 | – | – | 0.016 |
| Left temporal | H = 12.234, p = 0.002 | – | 0.045 | 0.002 | Right temporal | H = 14.258, p < 0.001 | – | 0.006 | 0.002 | |
| Left parietal | H = 19.117, p < 0.001 | – | 0.009 | <0.001 | Right parietal | H = 20.599, p < 0.001 | – | 0.016 | <0.001 | |
| Left occipital | H = 24.418, p < 0.001 | – | <0.001 | <0.001 | Right occipital | H = 13.880, p < 0.001 | – | – | <0.001 | |
P-values are FDR-corrected for Kruskal–Wallis test. The post hoc P-values are DSCF-corrected for multiple comparisons between groups and only the significant parts are shown in the figure. Significant p-values between HC and MCI are in bold. HC, healthy control; MCI, mild cognitive impairment; AD, Alzheimer’s disease.