Fig. 6.

Rescue of TCDD-induced cell spreading by overexpression of AhR in MEFs. A Rescue after 2 h exposure to TCDD and wound healing by 50 ng of pcDNA-HA-AhR in Jdp2^−/− MEFs. B Addition of 50 ng TCDD repressed the cell spreading activity of WT MEFs by 60–70% but did not affect cell spreading of Jdp2.^−/− MEFs. This repression was rescued by the forced expression of AhR. The relative wound area was measured. Data represent the mean ± SEM (n = 5). Data were analyzed using one-way ANOVA with the Tukey post hoc test (**p < 0.01)