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. 2023 Aug 17;22:217. doi: 10.1186/s12933-023-01940-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Acyl-GIP regulates adipocyte size and gene expression in subcutaneous fat of LDLR-/- mice. (A) Relative gWAT and iWAT GIPR gene expression of vehicle (gWAT n = 5; iWAT n = 4) and acyl-GIP treated LDLR-/- mice (gWAT n = 5; iWAT n = 4). (B) Volcano plot showing differential expression and its significance (-log10(p-Value), limma-trend) and (C) frequency distribution of adipocyte cell sizes (µm2) of gWAT from acyl-GIP (RNA sequencing n = 5; histology n = 7) versus vehicle (RNA sequencing n = 5; histology n = 6) treated LDLR-/- mice. (D) Volcano plot showing differential expression and its significance (-log10(p-Value), limma-trend) and (E) frequency distribution of adipocyte cell sizes (µm2) of iWAT from acyl-GIP (RNA sequencing n = 5; histology n = 4) versus vehicle treated LDLR-/- mice (RNA sequencing n = 5; histology n = 4). (F) Gene ontologies (p < 0.0001) and KEGG pathways (Pvalue < 0.001) that are down regulated by acyl-GIP in sc fat. Representative terms from Supplementary Table 2 are depicted