Table 2.
HR and 95% CI for the risk of myocardial infarction stratified by time-weighted cumulative AIP, duration of high AIP exposure and time course of AIP accumulation
| Index | Case, n (%) | Incidence rate, per 1000 person-years | Model 1 HR (95% CI) | Model 2 HR (95% CI) | Model 3 HR (95% CI) | Model 4 HR (95% CI) | Sensitivity analysisa HR (95% CI) |
|---|---|---|---|---|---|---|---|
| Time-weighted cumulative AIP | |||||||
| Q1 (≤ -0.50) | 108 (0.79) | 0.72 (0.60–0.88) | Reference | Reference | Reference | Reference | Reference |
| Q2 (-0.50 to -0.12) | 168 (1.23) | 1.13 (0.97–1.31) | 1.56 (1.22–1.99) | 1.56 (1.23–1.99) | 1.40 (1.09–1.78) | 1.39 (1.09–1.78) | 1.38 (1.08–1.76) |
| Q3 (-0.12 to 0.28) | 225 (1.65) | 1.52 (1.33–1.73) | 2.09 (1.66–2.63) | 2.11 (1.68–2.66) | 1.71 (1.35–2.17) | 1.73 (1.36–2.19) | 1.72 (1.35–2.18) |
| Q4 (≥ 0.28) | 265 (1.95) | 1.79 (1.59–2.02) | 2.47 (1.97–3.09) | 2.62 (2.09–3.28) | 1.86 (1.45–2.39) | 1.89 (1.47–2.43) | 1.91 (1.49–2.45) |
| P for trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | ||
| Duration of high AIP exposureb | |||||||
| 0 year | 328 (1.06) | 0.97 (0.87–1.08) | Reference | Reference | Reference | Reference | Reference |
| 2 years | 199 (1.73) | 1.58 (1.38–1.82) | 1.63 (1.36–1.94) | 1.69 (1.42–2.02) | 1.45 (1.20–1.74) | 1.49 (1.24–1.79) | 1.46 (1.21–1.76) |
| 4 years | 133 (1.97) | 1.81 (1.53–2.14) | 1.86 (1.52–2.27) | 1.95 (1.59–2.39) | 1.52 (1.22–1.90) | 1.57 (1.26–1.96) | 1.58 (1.27–1.97) |
| 6 years | 106 (2.01) | 1.85 (1.53–2.24) | 1.91 (1.53–2.37) | 2.04 (1.63–2.54) | 1.48 (1.15–1.90) | 1.52 (1.18–1.95) | 1.54 (1.20–2.00) |
| P for trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | ||
| Time course of AIP accumulationc | |||||||
| Low time-weighted cumulative AIP with positive slope | 135 (1.02) | 0.93 (0.79–1.11) | Reference | Reference | Reference | Reference | Reference |
| Low time-weighted cumulative AIP with negative slope | 141 (1.01) | 0.92 (0.78–1.09) | 0.99 (0.78–1.25) | 0.90 (0.71–1.15) | 0.88 (0.69–1.11) | 0.89 (0.70–1.13) | 0.90 (0.71–1.14) |
| High time-weighted cumulative AIP with positive slope | 233 (1.64) | 1.51 (1.33–1.71) | 1.61 (1.31–1.99) | 1.69 (1.36–2.09) | 1.37 (1.10–1.71) | 1.36 (1.09–1.69) | 1.37 (1.10–1.71) |
| High time-weighted cumulative AIP with negative slope | 257 (1.97) | 1.81 (1.60–2.05) | 1.94 (1.58–2.39) | 1.80 (1.46–2.22) | 1.34 (1.07–1.68) | 1.42 (1.13–1.79) | 1.44 (1.14–1.81) |
| P for trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0003 | ||
AIP atherogenic index of plasma
Model 1: unadjusted
Model 2: adjusted for age and sex
Model 3: Model 2 plus further adjusted for education, income, smoking status, drinking status, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, history of hypertension, hyperlipidemia, diabetes at baseline
Model 4: Model 3 plus further adjusted for high sensitivity C-reactive protein, estimated glomerular filtration rate, total cholesterol, low-density lipoprotein cholesterol level, antihypertensive drugs, antidiabetic drugs, and lipid-lowering drugs at baseline
aSensitivity analysis was adjusted for covariables in Model 4 and further considering death as competing event
bHigh AIP was defined as AIP in the highest quartile
cMedian of cumulative AIP was − 0.12