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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Cancer Discov. 2023 Mar 1;13(3):570–579. doi: 10.1158/2159-8290.CD-22-0764

Figure 1. Genomic landscape of early-onset vs late-onset non-hypermutated colorectal cancer: AACR Project GENIE.

Figure 1.

(A) Mutation rates among 6,903 tumor samples from CRC patients. Non-hypermutated tumors were defined using a cutoff (red line) of 17.78+ mutations/Mb.

(B) Boxplot of adjusted mutation rates between early-onset and late-onset cases with non-hypermutated CRC. The residual of adjusted mutation rates and P-value were derived from models adjusted for race and ethnicity, sex, tumor site and histology, sequencing assay, and sample type.

(C) Forest plot and mutation frequencies of genes differentially expressed between early-onset and late-onset non-hypermutated CRCs in adjusted models that reached statistical significance (P<0.05). Genes with FDR<0.05 are shaded in dark grey.