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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Cancer Discov. 2023 Mar 1;13(3):570–579. doi: 10.1158/2159-8290.CD-22-0764

Figure 2. Racial/ethnic patterns of non-silent somatic cancer gene mutations among patients with early-onset non-hypermutated CRC.

Figure 2.

API, Asian or Pacific Islander; NHB, non-Hispanic black; NHW, non-Hispanic white. (A-B) Boxplots of adjusted mutation rate residuals (tumor mutational burden, TMB) across racial/ethnic groups for (A) early-onset and (B) late-onset non-hypermutated CRC. The residual of adjusted mutation rates and P-values were derived from models adjusted for sex, tumor site and histology, sequencing assay, and sample type.

(C-E) Mutation frequencies between genes differentially expressed between early-onset vs late-onset non-hypermutated CRC cases that reached statistical significance for (C) API, (D) NHB, and (E) NHW patients.