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. 2023 Aug 18;6:0212. doi: 10.34133/research.0212

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Copyright © 2023 Di Wu and Yi Sun

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Fig. 4. — Deletion of Rbx1 and Sag in T_reg cells leads to an early-onset fatal inflammatory disorder. (A) Representative images of Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p19, scale bar =1 cm). (B) Gross body weight of Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (n = 4). (C) Survival curves of Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (n = 19). (D) H&E staining of multiple organs from Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p20 to p21, scale bar = 200 μm). (E) Representative images of the peripheral lymph nodes (top) and spleen (bottom) from Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p19, scale bar = 1 cm). (F) Expression of CD44 and CD62L in T_con cells from peripheral lymph nodes of Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p20).