Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 18;6:0212. doi: 10.34133/research.0212

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Di Wu and Yi Sun

Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0).

PMC Copyright notice

Fig. 5. — Impaired suppressive function of Rbx1&Sag-deficient T_reg cells. (A) Representative images of distal colon after H&E staining (scale bar = 200 μm). (B) Expression of Foxp3 in CD4⁺ T cells in peripheral lymph nodes from Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice at p20. (C) T_reg/CD4⁺ ratios in peripheral lymph nodes from Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p19 to p20, n = 4). (D) T_reg cell numbers in peripheral lymph nodes from Foxp3^Cre and Foxp3^Cre;Rbx1^fl/fl;Sag^fl/fl mice (p19 to p20, n = 4). (E) Unsupervised cluster analysis of the transcriptional alterations in Rbx1&Sag-deficient T_reg cells compared to the Foxp3^Cre control T_reg cells with Fc > 1.5 and P < 0.05. (F) Differentially expressed genes related to T_reg cell function in CD4⁺YFP⁺ T_reg cells from Foxp3^Cre/wt and Foxp3^Cre/wt;Rbx1^fl/fl;Sag^fl/fl mice, determined by transcriptional profiling with Fc > 1.5 and P < 0.05. (G) Relative abundance of Bach2 mRNA in CD4⁺YFP⁺ T_reg cells from Foxp3^Cre/wt and Foxp3^Cre/wt;Rbx1^fl/fl;Sag^fl/fl mice, determined by transcriptional profiling. (H) GSEA of cytokine–cytokine receptor interaction genes in CD4⁺YFP⁺ T_reg cells from Foxp3^Cre/wt and Foxp3^Cre/wt;Rbx1^fl/fl;Sag^fl/fl mice, determined by transcriptional profiling with Fc > 1.5 and P < 0.05. (I) GSEA of olfactory transduction genes in CD4⁺YFP⁺ T_reg cells from Foxp3^Cre/wt and Foxp3^Cre/wt;Rbx1^fl/fl;Sag^fl/fl mice, determined by transcriptional profiling with Fc > 1.5 and P < 0.05.