Figure 1.

State of linkage disequilibrium (LD) among SNPs in the CACNA1C gene region, including 10 kbp upstream and downstream (LD Plot-r²). D' and r ² values are presented in Supplemental Table S1, S3. White boxes represent D' < 1, log of likelihood odds ratio (LOD) < 2. Pink and red boxes represent D' < 1 and LOD ≥ 2. Blue boxes represent D' = 1 and LOD < 2. Bright red boxes represent D' = 1 and LOD ≥ 2. The solid horizontal line above the LD plot represents the CACNA1C gene, including 10 kbp upstream and downstream of the gene. The yellow boxes in the structure of the CACNA1C gene represent exons, and the solid lines represent untranslated regions or introns. The gray arrows represent the direction of transcription. The red squares represent the SNP of interest in this study.