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. 2023 Aug 18;18(8):e0273890. doi: 10.1371/journal.pone.0273890

Table 32. Relationships noted throughout our analyses.

Taxonomic Level Relationship(s) Reason
Genus Bacteroides-Sutterella (+, both) Only core correlation consistent across both sample sets at all levels (12 MCNs).
Genus Bacteroides-Prevotella (-, ADHD) Only competition involving two Bacteroidetes taxa.
Genus Bacteroides-Streptococcus (+, ADHD) Streptococcus is one of only two Firmicutes genera to join cluster BB, through this connection.
Genus Butyricimonas-Clostridium (+, ADHD) Butyricimonas was only ranked by ATria in ADHD, and reported as ADHD differentially abundant by two methods (LEfSe and ALDEx2). Clostridium is one of only two Firmicutes to join cluster BB, through this connection.
Family-Genus Clostridiaceae-Odoricibacter (-, ADHD) Odoribacter was reported as ADHD-elevated by LEfSe. In ADHD competes with Clostridiaceae taxa that compete with multiple cluster BB members (including its centroid). Clostridiaceae was reported as ADHD-reduced (Control-elevated) by ALDEx2.
Family-Genus Enterobacteriaceae-Oscillospira (+, Control; -, ADHD) Only correlation ever to change sign from Control to ADHD. Taxa involved are in the same cluster in Control.
Genus Blautia-Oscillospira (-, Control)
Streptococcus-Blauta (+, ADHD)
Streptococcus-Oscillospira (-, ADHD)
Blautia is associated with obesity and Oscillospira with leanness. Oscillospira (FR) competes with every member of Blautia’s cluster (FL3) in Control. FL-FR competition only happens in Control.
In ADHD Streptococcus cooperates with Blautia (obesity) and competes with Oscillospira (leanness) Streptococcus-Blautia is the only time a cluster BB member (largest Bacteroidetes-dominant) ever cooperates with taxa from FL or FR (largest Firmicutes-dominant, collectively over 70% of the population).
Streptococcus is only ranked in ADHD, Blautia is ranked higher in ADHD, Oscillospira is ranked higher in Control.
Blautia’s cluster (FL1) is larger and more central in ADHD.). Oscillospira’s (FR) is larger and more central in Control.

Summary of notable relationships throughout our ecological analyses, and observations.